The company is also planning phased reopenings of its other 100 stores.
Nordstrom did not list what locations are closing but said it will start contacting employees who are affected.
It will also implement curbside pickup and returns and speed up digital services, CEO Erik Nordstrom said in a statement.
Nordstrom, based in Seattle, also says it will conduct health screenings for employees and provide masks for employees and customers when stores reopen.
Restructuring is expected to result in savings of approximately $150 million, Nordstrom said.
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